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Abstract Perinatal asphyxia is a well recognized clinical entity that confronts obstetricians and neonatologists almost daily. from the clinical and prognostic point of view, perinatal asphyxia represents a major topic. The outcome of perinatal asphyxia depend on the severity of hypoxia. perinatal asphyxia and its complications is one of leading causes of death and permanent disability in neonatal intensive care unit. Recently , cardiac troponin I ( cTnI) has been an area of interest. Troponin is an inhibitory protein complex located on the actin filament in all striated muscles , and consists of three subunits; T, C, I. Cardiac troponin I was measured as an indicator of cardiac injury for long time, but it has been in interest for prediction of poor neonatal outcome in perinatal asphyxia. This study was carried out on fourty neonates admitted to neonatal intensive care unit, in Elahrar zagzgig general hospital. Twenty healthy neonates were selected from the outpatient clinic to act as a control group. All neonates in this study were subjected to meticulous history taking and complete through clinical examination, relevant data obtained by history, clinical examination was done as regard gestational age, birth weight, sex,mode of delivery, risk factors, apgar score and neonatal resuscitation. Laboratory investigations include CBC, CRP, serum electrolytes kidney function tests, ABGs, cTnI and cranial sonar were done in both the studied groups. All data were tabulated and processed by usual statistical program. The following findings were obtained: 1-regarding clinical signs, the asphyxiated neonates showed variable signs of cardiac affection (tachycardia and bradycardia), murmurs respiratory signs ( tachypnea, lung crepitations and cyanosis) and neurological signs ( poor reflexes, abnormal tone, depressed. |