الفهرس 
THE ANTIPHOSPHOLIPID SYNDROMEOnly 14 pages are availabe for public view
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Abstract
Anti annexin A5 Ab is an antiphospholipid-binding protein, which numerous retrospective studies have found to be associated with a higher frequency of recurrent miscarriages (Matsubayashi et al 2001; Matsuda et al., 1994; Arai et al., 2003).
The purpose of this study was to determine association between the anti annexin A5 Ab IgG isotope and unexplained recurrent spontaneous abortions.
For this aim, 50 women were included in the study. They were divided to two groups:
• GROUP 1 (patients group): included 25 cases that had a history of at least two or more successive unexplained recurrent abortions in their first trimester.
• GROUP 2 (controls group): included 25 cases that had at least two successful full term pregnancies and no history of pregnancy loss.
Patients with known or definitive causes explaining the recurrent miscarriage were excluded from the study e.g.: abnormal blood sugar test (D.M.), fasting and two hour post prandial.
- Abnormal hysterosalpingography finding as: anatomical abnormalities, intrauterine adhesions.
- Abnormal thyroid function test. (T3, T4, TSH) to exclude hypothyroidism.
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Summary
- History of autoimmune diseases or positive antiphospholipids antibodies, as anticardiolipin Abs and antilupus Abs should be negative.
- Abnormal abdominal and vaginal U/S (to exclude uterine anomalies: like intrauterine fibroids and patulous uterine isthmus.
Ages of women are between 18 years to 40 years.
All patients don’t have any medical diseases causing abortion like DM or hypothyroidism.
All patients and controls were subjected to measurement of the level of anti-annexin IgM and IgG in the serum, for IgM we took 15 subjects as controls.
We used an enzyme linked immunesorbent assay (ELISA).
The following results were observed in patients group:
We found that 10 cases of the 25 patients were positive for ANX V IgG Ab (40%), in contrast for 7 controls of 25 women were found positive for IgG ANX V Ab (28%), with p = 0.276 >0.05 which is not statistically significant.
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Summary
In addition to previous results we found that 15 cases of 25 patients were found positive (60%) for ANX V IgM Ab, in contrast for 8 controls of 15 women (53.3%), with p =0.466 > 0.05 which is not statistically significant.
There was no statistical difference between both groups as regards age with mean value for patients 26.7 years, and for controls 27.6 years, with p value = 0.55 > 0.05 which is not statistically significant.
The mean for the number of abortions in patients was 3.68 with standard deviation ± 1.79 with significant difference between patients and controls.
What does emerge clearly from this study is that anti-AnxV antibodies of class IgG or IgM measured before the beginning of pregnancy are not predictive for the outcome of the pregnancy, and the antibody concentrations did not differ significantly between the two groups.
Conclusion:
Anti annexin A5 antibody of class IgG or IgM measured before the beginning of pregnancy are not predictive of the outcome of the pregnancy, and there is no association between anti annexin antibodies and unexplained recurrent pregnancy loss. And until now doctors depend only on ACL and LAC to determine APS accompanied by recurrent spontaneous abortions.