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Abstract About 30% of patients with cirrhosis have diabetes mellitus (DM). Nowadays, it is a matter for debate whether type 2 DM in the absence of obesity and hypertriglyceridemia may be a risk factor for chronic liver disease (Compean et al., 2009). Glucose intolerance is very common in liver cirrhosis of whatever etiology and _20% of patients have overt diabetes (H. Knobler and A. Schattner, 2005). When cirrhosis is HCV-related, the risk of diabetes is higher (Mason et al., 1999 and Caronia et al., 1999). HCV is prevalent in Egyptians and how much prevalent is related diabetes among Egyptians is the question? We aimed to assess the prevalence of diabetes mellitus in Egyptian patients with cirrhotic and non-cirrhotic chronic hepatitis c virus infection And to identify some risk factors linked to its occurrence in our studied population. By systemic random sampling, about eight hundred and twenty chronic hepatitis C (CHC) patients presented to the outpatient Clinics in National Liver Institute hospital Menoufyia University, between January and May 2012, were examined and screened for presence of associated diabetes mellitus. They were Egyptian of either sex and, their age were ranged from 18 -70 years and had detectable HCV RNA, and many had liver biopsy consistent with chronic hepatitis and significant fibrosis. Other CLD etiologies like HBV, hemochromatosis or drug induce DM like interferon or corticosteroids were excluded. |