الفهرس 
Antiovarian AntibodyOnly 14 pages are availabe for public view
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Abstract
This study was performed to assess the antiovarian antibodies before and after laparoscopic ovarian drilling And follow up patients in inducing ovulation, restoring regular menstrual pattern in women with polycystic ovary syndrome.
45 women with polycystic ovary syndrome were selected for this work from those attending the infertility clinic at Ain Shams University Hospital.
The diagnosis of polycystic ovary syndrome was based on clinical, sonographic and endocrinological documentation.
Those who had fulfilled the primary inclusion criteria (n=45) were scheduled for laparoscopic ovarian drilling and all those women were by sampled by blood samples before and after laparoscopic ovarian drilling to assess the antiovarian antibodies . Then follow up of the patients by hormonal profile before and after laparoscopic ovarian drilling
All participants were followed up for the next 6 months to evaluate the effect of the procedure on the clinical presentation and the occurrence of ovulation by serial vaginal ultrasound (folliculometry). Menstrual pattern.
Follow up of those women included in this study was done through repeated transvaginal ultrasound folliculometry which started at day 11 of the cycle and every other day according to the follicular size. Good response is achieved when at least one mature follicle reached 18 – 24 mm in diameter (Speroff et al, 1999). If there was no follicular response till 20th day of the cycle or if the size of the follicle becomes < 24 mm, this consider bad response (-ve result) (Yarali et al, 1999).
If delay of menstruation for one week had been occurred, pregnancy test was performed; positive pregnancy test was considered good response of therapy.
The collected data was organized, tabulated and statistically analyzed using SPSS software computer package version 12. For quantitative data the range, mean, standard deviations (±SD) were calculated. Wilcoxon signed rank test was used to compare type of menstrual cycles before and after treatment. Mann-Whitney test were performed to test type of menstrual cycles in relation to treatment modalities. For qualitative data, the number and percent distribution was calculated. Fisher exact test was used as a test of significance. Significance was adopted at p > 0.05 for interpretation of results of tested of significance.
After laparoscopic ovarian drilling, ovulation was detected in about 76% of patients (28 women out of 45) Compared to 63% (17 women out of 45) show no ovulation after LOD. However, this difference was found to be statistically non significant.
Antiovarian Antibody assessment show difference befor and after laparoscopic ovarian drilling and this difference was found to be statistically significant.
Although, these results regarding menstrual pattern (regular or irregular) were statistically significant (P = 0.001). Yet, it may require further studies with large number of patients
The results represent the good effect of laparoscopic ovarian drilling in management of oligomenorrhea and amenorrhea associated with PCOs.