الفهرس 
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Abstract
Tyhpoid fever is still an important health problem, and is Particularly prevalent throughout the tropics where it is one of the commonest causes of fever (Bahr. and Bell 1987). Therapy is usually limited to chloramphenicol, 00.-trimoxazole, ampicillin and amoxycillin (Christie, 1980). Development of resistance to these agents and their drawbacks make it important to study potential therapeutic alternative (Overture et al, 1973, Butler et al., 1973, Dawson and Roultadge, 1971, Feder1lflgand Adel, 1991).
The fluoroquinoln represent a new class of antimicrobial agents with a broad spectrum of activity. The newest of these agents now available in the United States is ciprofloxacin (Neu, 1988).
Ciprofloxacinis bactericidal activity against members of the enterobacteriaceae and lack of cross resistance with earlier quinolones suggested its usefulness in the treatment of typhoid and paratyphoid fevers (Chin and Neu, 19811).