الفهرس 
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Abstract
Procalcitonin (PCT) is the precursor of Calcitonin, site of formation is the CALC-1 gene on chromosome 11 of the human genome. After transcription from CT-DNA into mRNA the first translation product is Pre-procalcitonin, which then changes by different modification steps into PCT.
PCT is a peptide, consisting of 116 amino acids. PCT is enzymatically degraded into lower molecular weight peptides. The final product consists of 32 amino acids and is named Calcitonin. All precursors including PCT and the mature hormone peptide can be detected in serum of healthy humans. In septic patients only the 3-116 fragment is detectable not the complete PCT molecule. Site of synthesis for PCT in healthy persons are the C-cells of the thyroid. Expression of CT-mRNA takes place only in the neuron endocrine cells. Release occurs in the form of the post translational processed hormone.
Calcitonin enclosed in Golgi vesicles. This hormone plays an important role in the pathway and regulation of calcium and phosphate in the bone metabolism. The mechanism of the biochemical pathway and site of synthesis of PCT after bacterial infection. They investigated which factors affected the synthesis. Results show that in case of bacterial infection two mechanisms of synthesis.. This synthesis is limited but it plays an important role in the initiation of PCT synthesis in storage tissues of humans. This PCT burst is initiated in all storage tissues (>18h).