الفهرس 
NORMAL BONE MARROW ANATOMY, FUNCTION AND MRI APPEARANCEOnly 14 pages are availabe for public view
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Abstract
The bone marrow is one of the largest organs of human body producing the optimal supply of circulating platelets, white and red blood cells to meet the body’s requirements for coagulation, immunity and oxygenation. In pediatric with blood disease, it can be affected by various conditions e.g. marrow proliferation, marrow replacement, marrow depletion and hemoglobinopathies and disorder of hematopoiesis.
MR imaging has become an important noninvasive tool that can provide the clinicians with important information for the diagnosis, staging and monitoring of therapy in pediatric patients with hematologic diseases by assessing a large volume of bone marrow noninvasively and relatively quickly.
Our study showed that MRI bone marrow examination is of high value in diagnosis of diffuse or localized marrow lesions and helped in detection of the site of marrow lesion especially in cases with focal infiltrative marrow lesions with false -ve blind aspiration cytology as lymphoma and so précised the site of marrow biopsy.
Serial MR imaging studies after initiation of therapy may obviate the need for some of the required bone marrow biopsies and may help explain the source of histologic findings.
On MRI follow up we can evaluate the course of the disease and determine response to treatment instead of repeated biopsies. Recently DWI with ADC measurement values are potentially useful tool that provide unique prognostic information and follow up finding.
MRI of bone marrow can detect the marrow complication of therapy as hemosidrosis that occur in cases of repeated blood transfusion with inadequate iron chelating therapy such as cases of thalassaemia and sickle cell anemia, due to iron deposition within marrow. Also detecting diffuse or focal marrow depletion in chemotherapy and radiotherapy.
MR imaging may, perhaps in the future, help us understand more of pathogenesis and evaluate hematologic malignancy.