الفهرس 
Background about quinolonesOnly 14 pages are availabe for public view
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Abstract
The pharmacokinetic properties of levofloxacin alone and with amprolium or
toltrazuril were determined in broiler chickens after single IV and orally administered doses of 10 mg/kg .b.wt. After IV and oral administrations, the plasma concentrationtime
graph was characteristic of a two-compartment open model. The elimination
half-life and the mean +/- residence time of levofloxacin for plasma were 4.07 +/- 0.24 and 5.4 ± 0.26, 3.89 ± 0.24 and 4.77 ± 0.28, 4.1 ± 0.45 and 5.38 ± 0.36 h, in
control, amprolium and toltrazuril respectively, after IV administration and 4.24 ± 0.28and 6.59 ± 0.44, 3.22 ± 0.13 and 4.93 ± 0.16, 2.98 ± 0.11 and 4.82 ± 0.13 h, in
control, amprolium and toltrazuril respectively, after oral administration. After single
oral administration, enrofloxacin was absorbed slowly, with time to reach maximal plasma concentration of 1.32 ± 0.096, 0.92 ± 0.057 and1.3 ± 0.037 h, in control, amprolium and toltrazuril respectively. Maximal plasma concentration was 3.27 ±
0.13, 2.17 ± 0.097 and 2.95 ± 0.11 μg.ml-1, in control, amprolium and toltrazuril respectively. Oral bioavailability was found to be 107.47 ± 9.23, 75.74 ± 4.5 and 53.51 ± 2.45%, in control, amprolium and toltrazuril respectively. Residues of levofloxacin in fat, kidney, liver, lungs, breast muscles, and spleen were measured in
chickens that received an orally administered dose of 10 mg/kg once daily for 3 days.
The results indicate that levofloxacin residues were cleared slowly. Mean muscle,
liver, and kidney concentrations of the levofloxacin ranging between 0.045 and 0.2 μg/g persisted on day 7 in chickens after dosing. However, at the time of slaughter (9 days), levofloxacin residues were only detected in liver and kidney with mean +/-concentration was 0.035 and 0.069 μg/g.