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Abstract applying functional tissue engineering (FTE) to the science of dentistry. Tissue engineering and regenerative medicine are emerging fields that have recently found their way into the dental field. Tissue engineering offers an attractive alternative involving the development of biological or hybrid substitutes for implantation into the body with the purpose of fostering, remodeling and regeneration of diseased tissue. Tissue engineering follows the principles of cell transplantation, materials science, and bioengineering towards the development of substitutes that would restore and maintain normal function. Research proved that stem cells could be used to treat many diseases such as Alzheimer’s, Parkinson’s, chronic heart conditions, and periodontal diseases as well as to grow replacement teeth and bone. As teeth are good source for stem cells storing them will be an excellent way to ensure the future biological needs for the individuals. That is why several cell banks around the world are starting to collect deciduous teeth and store them for future use. The objective of the present study was: To isolate dental pulp stem cells, test their multidifferentiation potential lineages and induce their odontoblastic differentiation using mechanical stimulation by applying compression pressure using a custom built hydrostatic pressure bioreactor. |