الفهرس 
AcknowledgementOnly 14 pages are availabe for public view
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Abstract
Since 1956 Wullestein succeeded in closure of the drum
perforation by use of full thickness skin graft. The trials started to use
many other materials such ~ vein by Zollner 1956, Temporalis fascia by
Shea 1960 and tragal perichondrium by Good hill 1964 (Vincent et al
1993).
Grafting a tympanic membrane perforation is nowadays a
relatively an easy surgical procedure as long as suitable material is
available for closure, but still every material has advantages and
disadvantages (James and Benecke, 2001).
In this study, we developed a new artificial eardrum patch for
healing TM perforations using water- insoluble chitosan.
The in vivo study of this CPS was done in Benha University
Hospital from May 2009 to February 2012.
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Series of ”40 ’*-ents” were collected from patients prepared
for myringoplasty. otr collection data were: patients with 15 small
and 25 medium*perforation, absence of any middle ear
, .”’(”
pathology or ossicubJr lesion (Fixation-. necrosis - discontinuity