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Abstract The aim of the work is to discuss a recent approach as regard new trends which introduced in the etiology, din— gnosis, pathogenesis and management of neonatal hyperbili-. rubinemia We discussed in details the role of green light,which is used since 1982, in the treatment of neonatal jaundice and its effect on bilirubin , converting it to “lumirubin” which may be the principal pathway for bilirubin execretion in bile and urine during phototherapy (Ennever et al.,1986). Hyperbilirubinemia is the most common problem experi— nced by the infant in the immediate neonatal period . Not only is the newborn infant unique because of his limited ability to clear bilirubin from the plasma, but also because the neonatal period remains the only time at which an elevated plasma bilirubin concentration represents a threat to the well bing of the infant (Maisels, 1982). Normal serum bilirubin varies in the neonatal period, it is 1—3 mg/dl. in the umblical cord serum , reaching 5—10 mg/dl. during the 3rd & 4th day and then decrease below 2 mg/dl. between the 5th—7th days of life. Unconjug— ated biliruhin represents 80% of serum bilirubin, while conjugated bilirubin represents 20% • The serum unconjuga— ted bilirubin will be increased in cases that increase the load of bilirubin to be metabolised by the liver, also in cases that may damage or reduce the activity of the enzymes (as in anoxia, infections, hypothermia and thyroid deficiency ) and lastly in cases that may combate for or block the enzymes (Seligson, et al., 1985). |