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Abstract Diabetes mellitus (DM) is a major public health Problem that is rapidly expanding world wide. Diabetic patients, including insulin dependent diabetes mellitus (IDDM) and non-insulin dependent diabetes mellitus (NIDDM), of sufficient duration are vulnerable to complications. One of the more frequent diabetic complications is diabetic foot, which results from complex interplay among three main complications of long-term diabetes: immunopathy, neuropathy and vasculopathy. The development of infection in the diabetic foot constitutes a foot care emergency, which requires urgent referral to a specialized foot-care team. The underlying principle is to detect the bacteria responsible and treat aggressively. Diabetic foot patient can create difficult diagnostic problem for physician and radiologist, yet current treatment concept stress the need for early and accurate diagnosis of the type and extent of the disease process in order to plane effective therapy. Clinical diagnosis need evaluation of the ulcer including its location, type and extent with detection of presence or absence of osteomyelitis. Microbiological diagnosis not only method of diagnosis of infection as all skin wounds contain micro organisms, so clinical signs of infection should be detected |