الفهرس 
Introduction & Aim of the workOnly 14 pages are availabe for public view
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Abstract
Background: Coronary heart disease is the leading cause of mortality worldwide Endothelial dysfunction is thought to be a key factor involved in the pathogenesis of athero-thrombogenic diabetic complication and are independent of other cardiovascular risk factors. Moreover, endothelial dysfunction is a predictor of future coronary events and coronary artery disease.CD144+ve EMP is expressed only by the endothelium and is considered to be a specific marker for quantifying endothelial cell microparticles and hence endothelial dysfunction. Objectives: The objective of this study is to investigate whether EMP (CD144) could be a useful marker of endothelial dysfunction and ACS in diabetic and non-diabetic patients. Patients and Methods: A prospective observation study included 60 acute coronary syndrome patients. The patients were classified into 30diabetic acute coronary syndrome patients (22 male ,8 female), 30non diabetic acute coronary syndrome patients(24 male,6 female). All patients and controls were subjected to full history taking, clinical examination as well as laboratory and radiological investigation.Special laboratory investigation: CD144 +ve EMP by flowcytomeric analysis. Results: Diabetic acute coronary syndrome patients had significantly CD144+veEMP percentages compared to healthy controls and compared to non-diabetic acute coronary syndrome patients(p=>0.0001, p=>0.0001 respectively). There were significant correlation between fasting blood glucose and HbA1c and CD144+ve EMP.(p=0.0001,p=0.0004).Conclusion: CD144+ve EMP is an endothelial dysfunction marker allow access to a typically inaccessible tissue; the endothelium. The CD144+ve EMP are elevated in acute coronary syndrome patients especially in diabetic patients. DM, smoking and hypertension are associated with elevated CD144+ve EMPs.