الفهرس 
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Abstract
Rift valley fever (RVF) is an acute or peracute viral, infectious and highly fatal zoonotic disease. It affects many animals’ species with highly economic losses. It is transmit to human begins and has the importance in public health.
The control by vaccination of susceptible animals is very important
as the corner stone of disease eradication. This study is applied to evaluate the immune response and duration of immunity in sheep vaccinated with the prepared vaccine (smith burn virus mixed with 0.2 μg/ml of Queel A before inoculation by one hour) in a comparison to different kind of vaccines ( inactivated , live attenuated Smith burn RVF vaccines).and overcome the disadvantages of inactivated RVF vaccine as high cost, the requirement for multiple dosing and
uncertain duration of immunity in adult and neonates, as well as overcome the disadvantage of live attenuated Smith burn vaccine as it’s teratogenic, abortogenic, fetal abnormalities, encephalitis, ability to return
virulent and pathogenic to human.
Through this study20 adult sheep (six months old, three of them were pregnant of one year old), three lambs (7-10 days of age)used for testing the safety of the prepared vaccine in this study.
The sera of these animals were collected after being tested proved
to be free from specific antibodies against RVF virus infection. The
animals were divided as the following:-
Two pregnant ewes and two lambs were inoculated with 10ml (5 ml S/C and 5ml I/P) used at safety test to prepared vaccine and one pregnant Summary
ewe and one lamb were kept as control. Seventeen adult sheep were divided into 4 groups. 1st.group: Composed of five sheepinoculatedS/Cwith a ml of prepared vaccine, 2nd.group: Composed of five sheep inoculatedS/C with aml inactivated RVF vaccine. 3rd.group: Composed of five sheep inoculatedS/C with a ml live attenuated smith burn RVF vaccine. 4th.group: Two sheep not vaccinated and kept as control.