الفهرس 
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Abstract
Breast cancer is the most frequently diagnosed cancer and the leading cause of cancer death among females worldwide. Obesity is a worldwide epidemic that continues to grow at an alarming rate. Moreover, obesity has been associated with the development of several malignancies, particularly hormone-dependent cancers such as, ovarian, endometrial and breast cancer.
In the present study, we evaluated the levels of resistin, FSG, PPG, insulin, insulin resistance, SHBG, albumin and free E2 as biomarkers in a case-control study of 40 obese breast cancer females’ and 40 apparently healthy obese controls. Serum resistin levels were determined using a ready-for-use ELISA kit. FSG, PPG and albumin were determined by colorimetric method. Serum insulin and SHBG levels were determined using ready-for-use IRMA kits. Insulin resistance was estimated by using homeostasis model assessment-(HOMA-IR). Serum total E2 levels were assayed using a ready-for-use RIA kit. Serum free E2 levels were estimated using an equation based on the law of mass action and depends on the fractions of E2 bound to albumin, SHBG and total E2.
In the present study, serum levels of resistin, FSG, insulin, insulin resistance and free E2 in obese breast cancer group were significantly higher than those of obese control group whereas PPG showed a non-significant difference. Statistical analyses showed that these might be a close correlation between all these biochemical parameters and breast cancer risk based on these finding, our results seem to suggest a possibility that high levels of resistin, glucose, insulin, HOMA-IR, free E2 and lower concentrations of SHBG and albumin could be a new risk factor for breast cancer and to provide a new insight into understanding of the association between obesity and breast cancer risk.
In the current study, no significant correlations were found between studied biochemical parameters and clinicopathological parameters.
Conclusions:-
from this study, it could be concluded that:
1. Obesity is a worldwide epidemic that continues to grow and associated with many diseases and mortality.
2. Serum resistin, FSG, insulin, insulin resistance and free E2 may have a risky role in incidence of breast cancer.
3. No significant correlation was found between serum levels of resistin, insulin, insulin resistance, SHBG and free E2 and clinicopathological parameters. Also, no significant correlation was observed between serum resistin, insulin, insulin resistance, SHBG and free E2 and disease-free survival of breast cancer patients. This indicates the absence of the prognostic role for these biochemical parameters in postmenopausal breast cancer patients.