الفهرس 
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Abstract
The present work was carried out to elucidate the toxic effect of a drug fansidar® that is a fixed combination of two antimalarial agents pyrimethamine (25 mg/tablet) and sulfadoxine (500 mg/tablet) that have been used extensively worldwide for the treatment of chloroquine resistant plasmodum falciparum malaria, toxoplasmosis and pneumocystis carinii pneumonia in patients with the acquired immunodefiency syndrome . Folic acid used to avoid or at least to reduce toxic effects of fansidar drug. The present work searched for the genotoxic and physiological effects of antimalarial drug fansidar (pyrimethamine – sulfadoxine ) and / or the protective effect of folic acid in vivo using albino rat. The current study is divided into two main parts: 1- The cytogenetic studies which included: • Chromosomal aberrations assay. • Estimation of the frequency of abnormally shaped sperm cells. 2- The physiological studies which included: • Effect on follicle stimulating hormone (FSH) and testosterone hormone (TH). • Effect on blood picture parameters (CBC). Finally, the results in the present work indicated that, although antimalarial drug fansidar administered to male albino rats as a single dose 18.9mg/rat/day (used in malarial treatment ), the drug causes clastogenic effects on the level of chromosomal aberrations, abnormally shaped sperm cells , testosterone hormone as well as some blood picture parameters .The administration of folic acid supplement prior to treatment with fansidar help to attenuated the side effects of treatment with fansidar alone.