الفهرس 
Introduction
Pathophysiology of diabetesOnly 14 pages are availabe for public view
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Abstract
Diabetes is a metabolic disorder characterized by chronic hyperglycaemia with disturbances of carbohydrate, fat and protein metabolism. This results from defects in insulin secretion, insulin action, or both (Gardner et al., 1997). The effects of diabetes include long-term damage, dysfunction and failure of key organ systems. The prevalence of diabetes is increasing in the UK, standing at 4.3% in 2005, compared to 2.8% in 1996. While the incidence of type 1 diabetes is static, the incidence of type 2 diabetes is rising rapidly. This trend is expected to continue with some models predicting a prevalence of 9% (range6.3e13.3%) by 2025. The disease is associated with microvascular, macrovascular, and metabolic complications (Diagnosis and Classification of Diabetes Mellitus. 2010).
If we are to reduce morbidity and/or mortality of DM, we must identify people at risk for type 2 diabetes in order to make an appropriate intervention (Alberti et al, 1998). The burdens diabetes places on healthcare are great, both financially and on an individual patient’s quality of life. Excellent anaesthetic management of the diabetic patient throughout the operative journey is key to a successful outcome and efficient use of resource (Diagnosis and Classification of Diabetes Mellitus. 2010).