الفهرس 
Introduction & aim of the workOnly 14 pages are availabe for public view
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Abstract
Primary immunodeficiency disorders in childhood usually present as unusual, recurrent or severe infections. In many of the primary immunodeficiency disorders, thereare known patterns of inheritance, and other family members may be affected. Some primary immunodeficiency disorders are relatively common, such as selectiveIgA deficiency, and often do not lead to major morbidity. Others, such as the severecombined immune deficiency syndromes, are relatively rare, and are fatal in early life if notrecognized and treated early. Diagnosis of a primary immunodeficiency disorder depends on appropriate use oflaboratory investigations. Often there will be abnormalities detected on a complete blood count and measurement of immunoglobulin isotypes. More complex investigations should be undertaken in conjunction with a pediatric immunology service. We analyzed the immunological profile of 100 children suspected to have primary humoral immunodeficiency and comparing their results to 50 healthy controls of matched age and gender. This immunological profile included serum IgG, IgA, IgM, specific antibody response to tetanus toxoid, B cell count, B cell subsets (naive, switched memory cells and non switched memory cells), total lymphocytic count, T cell count, T cells subsets (T helper and T cytotoxic), serum C3, serum C4 and NBT test.