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المستخلص Obesity is becoming a significant problem for many countries around the world. Rates of obesity have reached epidemic levels, and both developed and developing countries are now affected. It has more doubled in prevalence in the last 30 years. The global prevalence of obesity has increased considerably in the last decade. According to estimates of the world health organization(who),80 % of the world population was primarily based on traditional methods of healing which use medicinal plants and folk knowledge. Phytotherapy is the treatment and prevention of diseases using plants, plants part such as fruits, flowers, leaves, and roots or mixtures of them, these plants called medicinal plants, or herbs. The aim of recent studying the effect of some plant materials and herbs which were suggested in folk medicine for treating obesity, after knowing their active constituents and their biological activities, using experimental animal (Rats). This study used species of herbs and plants, which are used individuals and as mixture of them to form photogenic diet for treatment obesity. All herbs and plants were milled by using a precession mill to give a powder and were kept in plastic bags in a cool and dry location for using, all herbs and plant are best in a cool, dry and dark location to reduce oxidation of their contents. Thirty two female albino rats, each weighing 210±59g, eight weeks age were used this investigation. All rats were the control diet for 5 days before beginning of the experiment for adaptation. The rats were divided into (8) groups of (4) rats each with similar total weigh and were housed as twice in the cages. All obese rats were fed the experimental diet (basal diet) for 4 weeks without or with herbal powder, and there is one group continues with high fat diet plus herbal mixture. The rats divided into the flowing group:- - Group 1: Rats fed on basal diet as negative control. - Group2 :Ratsfed on basal diet with fat to as positive control. - Group3: Rats fed on basal diet with cake with (2.5%) chicory. - Group4: rats fed an diet with cake supplemented with (5%) chicory. - Group5: rats fed on diet with cake supplemented with (2.5%) senna. - Group6: rats fed on diet with cake supplemented with (5%) senna. - Group7: rats fed on diet with cake supplemented with (10%) myrrh. Group8: rats fed on diet with cake supplemented with (1.5%) myrrh. Biological evaluation of the different diets was carried out by determination of body weight gain (BWG%), food efficiency ratio (FER). at the end of the experiment, Blood samples were collected for using to determination of the following parameters:- serum lipids / uric acid / creatinine / urea / glutamic oxaloacetic transaminase (ALT ) and glutamic pyruvic transaminase(AST) / Alkaline phosphatase (ALP) The Kidney, spleen, lunge, liner and heart with aorta of each rat were removed, cleaned in saline solution and dried then weighed separately for histpathological examination. The data were analyzed using a completely randomized factorial design SAS (1988). The results were out put as following: 1) Biological evaluation The control negative was point to very high significant differences p< 0.01, when compared with control positive and all other groups for initial weight .Regarding to final weight, the diets were cosisited Cichorium intybus (chicory), continue high lipid, commercial, herbal mixture were revealed to very high significant differences p<0.001and Cassia occidentalis (Senna), Commiphora myrrh (myrrh) p< 0.05 comparing with control positive .The control negative and the diets were cosisited , Cichorium intybus (chicory), Commiphora myrrh (myrrh), continue highlipid were refered very high significantdifferences p<0.001and Cassia occidentalis(Senna)., commercial p< 0.05 comparing with control positive for food intake .Finally as for percentage of weight gain and food efficiency ratio all groups showed very high significant differences p< 0.001 comparing with control positive while no significant differences between control positive and control negative . 2) Serum Lipid The control negative and the diets were cosisited Cichorium intybus (chicory), continue high lipid, commercial, herbal mixture, Cassia occidentalis (Senna)., Commiphora myrrh (myrrh) were referred very high significant differences p< 0.001 comparing with control positive for total lipid, triglycerides, LDL ,VLDL, Cholesterol except between cholesterol the degree of differences at p< 0.05 .As for HDL no significant differences between other group and control positive. The diets were consisted showed very high significant differences p< 0.001 and Cichorium intybus (chicory), commercial p< 0.05 comparing with control positive for phosphlipid and no significant differences between other group and control positive Regarding to heart weight control negative and the diets were cosisited Cassia occidentalis (Senna), continue highlipid showed high significant differences p< 0.001 and Cichorium intybus(chicory), Commiphora myrrh (myrrh), commercial p<0.05 comparing with control positive .As for kidney weight the diet was consisted Cichorium intybus (chicory) refered high significant differences p < 0.001and herbal mixture p<0.05 comparing with control positive while no significant differences between control negative, Cassia occidentalis(Senna) , Commiphora myrrh (myrrh), continue high lipid, commercial and control positive . The control negative and the diets were cosisited Cichorium intybus (chicory), continue high lipid, commercial showed high significant differences p<0.001 and Cassia occidentalis(Senna) , Commiphora myrrh (myrrh) p< 0.05 comparing with control positive for liver weight .As for lung and spleen no significant differences between all groups and control positive . 4) Liver Function Regarding to ALT no significant differences between all groups and control positive. The diet was consisted herbal mixture showed high significant differences p< 0.05 comparing |