الفهرس 
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Abstract
INTRODUCTION
Patients suffering from portal hypertension frequently bleed t’rom esophageal varices.
This is a dramatic event accompanied by n high incidence of mortality which is about
50% after the first hemorrhage (Rigo eta! 1992).
The factors that predispose to and prccipit lte v 1riccal hemorrhage have still not been
clenrly identified (klacll111fluma eta/ 1992).
!n normal individunls bleeding can result ti·om localized hyperfibrinolysis.
Any ammmt or localized fibrinolysis could exaggerate local bleeding and favorably intluenced
by fibrinolytic inhibitors (Prentice
1975). Certain lesions that cause upper or lower gastrointestinal bleeding
have been associated with increased local fibrinolytic nclivity e.g. cirrhosis
of the liver and bleeding due to esophageal V<lrices (0/(a and Tattttlur
1979).
The mm of this work is to study the relationship between local fibrinolytic activity
(i.e. in gastric juice) and bleeding tendency in cases of esophageal varices. This
rel3tionship, if’ present, will be very useful in management and prophylaxis against
bleeding episodes which are very dangerous.