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Abstract The present study was carried out experimentally on 35 healthy and adult donkeys of both sexes. Three animals of them were used for anatomical consideration of the carpal joint. Fourteen animals were for serial propagation of the Staph. aureus till reach to the infective inoculums. The remaining 18 donkeys were used for induction of septic arthritis of the radiocarpal joint and subjected for further investigations suggested in the plan of the study. Prior to the induction of septic carpitis, the normal general health conditions of the animals as well as the synovial fluid analysis and their bacteriological examination, normal radiographic appearance, normal ultrasonographic images and normal arthroscopic findings of the radiocarpal joint were assessed. Following the induction of septic carpitis the clinical signs appeared on the animals were recorded. The infected radiocarpal joints were subjected again to the aforementioned methods of diagnostic investigations for assessment of the pathological changes that accompany the infection. Then the animals were divided into 3 groups as the following:- Group I:- The treatment of the animals of this group began 3 days after induction of septic arthritis of the radiocarpal joint. Group II:- The treatment of the animals of this group began 14 days after induction of septic arthritis of the radiocarpal joint. Group III:- The treatment of the animals of this group began 28 days after induction of septic arthritis of the radiocarpal joint. To confirm of the diagnostic findings by the aforementioned investigation, the radiocarpal joint from each group before and after treatment was subjected to gross as well as histopathological examination. The regime of treatment:- The experimentally induced septic carpitis in donkeys was treated as the following:- All infected radiocarpal joints were daily intravenously injected by gentamicin and phenylbutazone as well as joint lavage, which repeated twice, fourth, three times in group I, II and III respectively. Daily follow up of the treated animals in each group was performed. When the clinical inflammatory was subsided or disappeared, the radiocarpal joints were subjected to the aforementioned diagnostic investigations to estimate the effectiveness of treatment for the radiocarpal joint in each group of animals. |