الفهرس | Only 14 pages are availabe for public view |
Abstract Myocardial infarction has been an important cause of cardiovascular morbidity and mortality in recent years. It can be induced expiremently by ISO.NAC was shown that it exhibits antioxidant, antiangiogenic, and anticancer activities.NAC also acts as a cysteine donor and maintains the intracellular levels of glutathione . It has been demonstrated that NAC is able to inhibit oxidative stress and DNA damage.Since increased free radical production has been implicated in the development of MI, we undertook the present study to evaluate the protective effects of NAC on cardiac marker enzymes,ECG, and histopathology of myocardium. This study was carried out on 4 main groups of adult male albino rats. The first of them is the control group received no medications. The 2nd group received NAC at a dose of 10gm/kgm/day orally for 2 weeks.The 3rd group injected with ISO in a dose of 100mg/kgm SC for 2 days ( the 15th and the 16th days) for induction of ischemia. The 4th group received NAC at a dose of 10gm/kgm/day orally for 2 weeks before ISO injection SC for 2 days. The parameters used to evaluate myocardial infarction were serum CK-MB, serum LDH,T-wave voltage, and histopathology study. These parameters were estimated at the end of the study. |