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Abstract The co=on housefly, Musca domestica is one of the dominant species found in human habitations, in tropical and subtropical regions, it has gained importance as a serious vector of many infectious diseases of public health as cholera, typhoid and dysenteries .... etc. In Egypt it was recorded as a potential vector of diseases since ancient time. Sanitary or environmental conditions provide a suitable facility for propagation and prevalence of diseases and vector. Conventional insecticides play an important role in the overall fly suppression program. However, their intensive use has been challenged, especially by the housefly, through the development of resistance of these chemicals and their serious side effects, including genetic damage to the associated microorganisms, plants, animals and mankind itself (Garrett et al., 1986). For instance Organophosphorous pesticides are kno\vn to react \vith DNA generally as alkylating agents and consequently they are potential mutagens in a variety of organisms (\Vaters et al., 1980). At present, Pyrethroids have potential for the control of house hold and agricultural pests, and show particular promise for controlling pests of public health because of their advantages over other chemical insecticides. Entomologists have long suspect that a change in the target enzyme by an insecticide can be ultimate fertility mechanism. A group of enzymes referred to as dehydrogenase were biochemically investigated in a wide variety of insects, the relative activities of the insect dehydrogenases may be related to the function and energy demands of the different tissues subjected for alternation by insecticides. |