الفهرس 
o Nerve injury.Only 14 pages are availabe for public view
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Abstract
Mesenchymal Stem cell therapy & melatonin holds great promise for the repair of injured tissues and organs, including the peripheral nerves. The aim of the present study was to demonstrate the effect of transplanted mesenchymal stem cells & melatonin on nerve regeneration in experimentally induced peripheral nerve injury in rats. Fifty adult female albino rats were used. The rats were classified into five groups; the first group was the normal control group and the second group was peripheral nerve injury non treated group , and the third group the peripheral nerve injury mesenchymal stem cell treated group , the fourth was the peripheral nerve injury melatonin treated group , the fifth were the peripheral nerve injury melatonin & mesenchymal stem cell treated group ,48 hours post injury retro-orbital blood samples were used to estimate MDA and total antioxidant capacity . The walk track analysis were done preoperative and 1 & 2 months post injury eight weeks post injury electrophysiological assessment including the nerve conduction velocity and electromyography were done and BDNF were measured using the real-time PCR method in all groups 2 weeks post injury . The rats were sacrificed and nerve was excised for Histopathological studies. Mesenchymal Stem cell therapy & melatonin holds great promise for the repair of injured tissues and organs, including the peripheral nerves. The aim of the present study was to demonstrate the effect of transplanted mesenchymal stem cells & melatonin on nerve regeneration in experimentally induced peripheral nerve injury in rats. Fifty adult female albino rats were used. The rats were classified into five groups; the first group was the normal control group and the second group was peripheral nerve injury non treated group , and the third group the peripheral nerve injury mesenchymal stem cell treated group , the fourth was the peripheral nerve injury melatonin treated group , the fifth were the peripheral nerve injury melatonin & mesenchymal stem cell treated group ,48 hours post injury retro-orbital blood samples were used to estimate MDA and total antioxidant capacity . The walk track analysis were done preoperative and 1 & 2 months post injury eight weeks post injury electrophysiological assessment including the nerve conduction velocity and electromyography were done and BDNF were measured using the real-time PCR method in all groups 2 weeks post injury . The rats were sacrificed and nerve was excised for Histopathological studies. improvement in the mean value of nerve conduction velocity and sciatic function index and total antioxidant capacity and enhanced expression of BDNF and significant decrease in the MDA enzyme when compared with the corresponding values in nerve injury non treated group. Histopathological examination revealed significant improvement of nerve regeneration and increase number of myelinated axons.