الفهرس 
Introduction & Aim of the workOnly 14 pages are availabe for public view
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Abstract
Systemic Lupus Erythematosus is an autoimmune disorder characterized by multisystem microvascular inflammation with the generation of autoantibodies. Patients with SLE are subjected to myriad symptoms and inflammatory involvement that can affect virtually every organ. Renal involvement tends to occur within the first 2 years of SLE. It has a poor outcome. Objective: The aim of this work is to analyze the presentation, natural history and response to therapy in patients with SLE with and without nephritis attending the renal unit, rheumatology and immunology unit and internal medicine wards in Mansoura university hospitals. Methodology: This observational, analytic and longitudinal study was carried out on 75 patients (7 males and 68 females) with systemic lupus erythematous, attending the renal unit, rheumatology and immunology unit and internal medicine wards in Mansoura university hospitals during the period between December 2012 and December 2013 with regular monthly follow up. All patients underwent a thorough clinical evaluation, laboratory tests including: CBC, ESR, serum creatinine, urinalysis and immunological profile. Results: SLE was more common in female patients SLE activity was more related to pregnancy and lactation. The most frequent main initial manifestations were fatigue, mucocutanous, arthralgia and arthritis. The most manifested statistically significant observations with the renal group were male sex, associated hypertension, associated hospital admissions and death. Conclusion: SLE patients with renal affection are more prone to hospital admission and increase mortality risk. Male SLE experiences more violent disease and more susceptible for renal affection.