الفهرس 
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Abstract
The chemistry of diarylurea and diarylthiourea derivatives
has gained increasing attention due to its diverse
pharmacological properties such as antitumor, antiproliferative
and antibacterial activity and also as herbicide.
Reaction of phenyl isocyanate 1 with different aromatic
amines 2 gave the monoadduct 3a-e and the diadduct 4a in
case of p-phenylenediamine (Scheme 1).
Scheme 1
Similarly reaction of phenyl isothiocyanate 5 with paminoacetophenone
2b gave the monoadduct 6a. However
with 2,3-diaminopyridine 2c and o-phenylenediamine 2d gave
the monoadducts 6b-c and the diadducts 7a-b. On the other
hand, reaction of p-anisidine 2e with the same reagent gave the
monoadduct 6e and with p-phenylenediamine 2f gave the
diadduct 4b (Scheme 2).Scheme 3
Compound 4b was used as key intermediate for the
preparation of compounds 9-11 through its reaction with
diethyl malonate, ethyl chloroacetate and phenylhydrazine
(Scheme 4).Some of the synthesized compounds were evaluated for their
antimicrobial activities. The tested compounds were evaluated
against Gram –ve bacteria, Gram +ve bacteria and yeast.
The synthesis of urea, thiourea and amide derivatives through
three component reaction to study the antitumor activity of
some of the synthesized compounds has also been taken into
consideration.
Thus, reaction of anisaldehyde, resorcinol and acetamide in
one pot reaction gave compound 21, in the presence of POCl3
the cyclized compound 22 was obtained. Replacement of
acetamide by urea, thiosemicarbazide and thiourea compounds
24, 26 and 28 were obtained respectively (Scheme 9).