الفهرس 
INTRODUCTIONOnly 14 pages are availabe for public view
 |  | from | 204 |  |  |
| | | from | 204 | | |
Abstract
The aim of the present study was to evaluate the effects of laparoscopic ovarian drilling on ovarian reserve assessed by Anti-Müllerian hormone assay and ultrasonography in women with polycystic ovary syndrome. Therefore, the factors that may affect ovarian reserve assessment were excluded from the study. Women participating in this study were aged between 30 and 40 years, non-smokers, with no past or present history of ovarian surgery or pathology. Women with Other aetiologies of hyperandrogenism (congenital adrenal hyperplasia, androgen secreting tumours and Cushing’s syndrome) or with infertility due to any factor other than anovulation due to PCOS (e.g tubal or male factors) or neoplastic, metabolic (especially hyperprolactinemia, non classical congenital adrenal hyperplasia, Cushing’s syndrome, diabetes and thyroid diseases), hepatic, renal, CV diseases or any chronic medical illnesses were also excluded from the study.
This prospective cross-sectional study included seventy primary anovulatory women with PCOS randomly allocated to undergo LOD (n = 40) or receiving incremental doses (50–150 mg) of clomiphene citrate (n =30) and twenty healthy age-matched women with a regular menstrual cycle and normal ovaries (by ultrasound examination).
Diagnostic criteria for PCOS were according to Rotterdam ESHRE/ASRM consensus in 2003. These criteria included at least two of the following three features: (a) oligo- or anovulation, (b) clinical and/or biochemical signs of hyperandrogenism, or (c) polycystic ovaries by sonographic features.
This study was conducted between May, 2011 and May, 2012 and all enrolled women were recruited from the attendants of the Out patient Clinic and Endoscopy Unit of the Obstetrics and Gynecology Department of Suzan Mubarak University-Maternity Hospital, El-Menia University. The study was approved by the Local Ethics Committee for Research, Department of Obstetrics and Gynecology, Faculty of Medicine, El-Menia University. All women were informed about the study and a detailed written informed consent was taken from all participants prior to the study.
All enrolled women were subjected to full detailed history either medical, surgical, past history, obstetric history or sexual history with a special stress on menstrual pattern, fertility status, any previous investigations or treatment given to the patient for PCOS. Thorough general examination was done with special stress on anthropometric measurements (including body weight, height, body mass index and waist/hip ratio) and clinical manifestations of hyperandrogenism (including hirsutism, acne and male-pattern alopecia). Local pelvic examination was done to evaluate the size of the uterus and ovaries and exclude any pelvic pathology.