الفهرس 
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Abstract
Introduction: The role of vitamin D in the regulation of calcium and bone metabolism is well established. Newer physiologic functions for vitamin D have been identified. Vitamin D plays a vital and complex role in immune system function and regulation.
Aim: study the effect of intravenous calcitriol treatment on the immune system in chronic regular haemodialysis patients through the study of serum levels of IL-6 and IL-8 before and after calcitriol therapy in addition to study the changes in serum level of total calcium & ionized calcium & phosphorus & alkaline phosphatase and intact parathyroid hormone before and after calcitriol therapy.
Methods: This study was conducted on 45 subjects randomized into three groups. 15 subjects control group ( group 1 ) and thirty end stage renal disease patients on chronic hemodialysis will be randomized into two groups group 2( not receiving calcitriol ) and group 3( receiving calcitriol ) Blood samples were withdrawn before entering the study and after 1 and 3 months for the measurement of serum levels of Total calcium,Ionized calcium,Phosphorus,Intact PTH (iPTH),Alkaline phosphatase (ALP). , Interleukin – 6 (IL-6) andInterleukin – 8 (IL-8).
Results: Calcitriol treatment effectively suppresses iPTH , significant increases in the serum total calcium and ionized calcium, increases in the serum phosphorus , decreases serum ALP levels significant decrease in the serum level of IL-6and significant decrease in the serum level of IL-8.
Conclusion: we propose that haemodialysis patients with secondary hyperparathyroidism should be treated with intravenous calcitriol not only due to its role in the regulation of calcium and bone metabolism but also vitamin D plays a vital and complex role in immune system function and regulation
KEY WORDS:
Calcitriol -immunity -chronic kidney disease.