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Abstract Summary Pulmonary hypertension is defined as an increase in mean pulmonary arterial pressure (mPAP) ≥25 mmHg at rest as assessed by right heart catheterization. Pulmonary hypertension is a rare disorder that can be present in women of child-bearing age. During pregnancy, It is associated with high morbidity and mortality in all defined clinical groups of pulmonary hypertension. Therefore, pulmonary hypertension is regarded a contraindication for pregnancy. However, sometimes women become pregnant despite being advised against pregnancy, or pulmonary hypertension is newly diagnosed during pregnancy. These women are usually advised to terminate the pregnancy even though termination itself is also associated with maternal risks. Some women do not regard termination as an acceptable option and carry on with their pregnancy. The normal physiological changes of pregnancy are poorly tolerated by women with pulmonary hypertension. Pregnancy is associated with increased plasma volume and decreased systemic vascular resistance, both resulting in an increase in cardiac output. Fatigue and exertional dyspnoea are Intensive Care Management of Pulmonary Hypertension With Pregnancy Summary 53 the most frequent presenting symptoms. They are due to reduced cardiac output and impaired oxygen transport. Chest pain is often present and reflects right ventricular ischemia. Syncope can result from low cardiac output. Several signs of right heart failure, such as hepatomegaly, ascites, and ankle edema, may be hard to identify during pregnancy or resemble normal pregnancy. Elevated jugular venous pressure and a loud pulmonary component of the second heart sound are useful signs that point to the diagnosis. Echocardiography will usually reveal the diagnosis. The threshold to perform echocardiography should be low during pregnancy in women with dyspnea. Right heart catheterization is required to confirm the diagnosis and gives useful additional information on pulmonary vascular resistance and cardiac output. It can be performed with relatively low fetal risk since radiation can be avoided. During pregnancy, it should be reserved for women in whom the results have therapeutic consequences, because of the associated risks of thromboembolism and infection. Functional capacity needs to be evaluated (New York Heart Association or World Health Organization functional class) and exercise capacity can be assessed with an un-encouraged six-minute walking test. Intensive Care Management of Pulmonary Hypertension With Pregnancy Summary 54 When pregnancy occurs, termination should be offered even if the woman is in a good clinical condition. Pregnancy termination is a high-risk procedure and it should be performed in an experienced centre. When the woman chooses to continue pregnancy, it is important that she is managed by a multidisciplinary team in a centre licensed for the treatment of pulmonary hypertension patients. The team should include a pulmonary hypertension specialist, a cardiologist, obstetrician and anesthetist specialized in managing high risk pregnancies, and a neonatologist. The woman must be followed at least monthly. The cardiac demands should be minimized by rest and a low salt diet. To avoid caval vein compression, the patient should lie in the lateral position. Hospital admission in the second trimester is often advised, though its benefit is unproven and a satisfactory outcome of pregnancy has been described when women were followed on an outpatient basis. Oxygen should be given when hypoxemia is present. Anticoagulation therapy should be continued when there is an established indication outside pregnancy. It should, however, be considered on an individual basis in other women, since there may be bleeding risk, for example in women with Eisenmenger syndrome or portal hypertension. When therapeutic anticoagulation therapy is given, it is mandatory that the anticoagulation effect is monitored carefully and Intensive Care Management of Pulmonary Hypertension With Pregnancy Summary 55 frequently, since dose requirements change during pregnancy with increase in plasma volume and glomerular filtration rate. When heart failure occurs, diuretics are the appropriate therapy, preferably furosemide. Spironolactone is contraindicated because of anti-androgenic effects. PAH-specific therapy includes Calcium channel blockers, epoprostenol, iloprost, treprostinil and phosphodiesterase type-5 inhibitors. On the management of pregnant women with heart disease ,it is advised that women who are on drug therapy for pulmonary hypertension continue this therapy during pregnancy. Since bosentan has teratogenic effects, patients should be informed about the fetal risks, and substitution with other targeted drugs is often advised. It is probably beneficial to start advanced therapy with prostacyclin analogues or sildenafil early during pregnancy. A timely delivery plan should be constructed and be available to all team members. The best mode of delivery is a matter of debate. Vaginal delivery is associated with volume changes during contractions which poses a problem in women with pulmonary hypertension since they have limited capability to increase their cardiac output. Moreover, pushing can have adverse hemodynamic effects. Planned cesarean delivery may therefore be a better choice, though vaginal Intensive Care Management of Pulmonary Hypertension With Pregnancy Summary 56 delivery is not considered absolutely contraindicated. In many cases, vaginal delivery will not be an option because early delivery is often necessary. When cesarean section is performed, general anesthesia has several disadvantages that should be taken into account. These include cardiodepression by volatile agents, and increase of pulmonary vascular resistance during intubation and positive pressure ventilation. A careful combined epidural and low-dose spinal anesthesia avoids vasodilatation. It can be safely applied by an experienced anesthetist and is probably the best option. During delivery, hemodynamic monitoring of arterial and central venous pressure is advised. Pulmonary artery pressure monitoring probably has more risks than advantages. Hospital observation is necessary until at least 2 weeks after delivery. Women with pulmonary hypertension should be advised against pregnancy. Adequate contraception should be installed. Barrier methods are safe but not sufficiently effective. Lowdose combined oral contraceptives containing ethinyl estradiol are not suitable for women with pulmonary hypertension since they are thrombogenic. Progesterone-only pills or dermal implants can be used. Endothelin receptor antagonists such as bosentan can reduce the efficacy of oral contraceptives. The levonorgestrelIntensive Care Management of Pulmonary Hypertension With Pregnancy Summary 57 releasing intra-uterine device is very effective and safe. Vasovagal reactions can, however, occur during implantation and may be poorly tolerated; therefore, women with pulmonary hypertension should have these devices implanted in hospital. |