الفهرس 
ABBOTTT HCV EIA Procedure:Only 14 pages are availabe for public view
 |  | from | 157 |  |  |
| | | from | 157 | | |
Abstract
In order to study the profile of distribution of hepatitis C virus among Egyptian infants and
children, Our study was done on 161 patients whoose ages ranged between two and
twelve years. llcj’d<l:’ ;J’
The patients were divided into four group’) ,
P ”L hcrc tM f, ’”\’
transfused group and the normal healthy children group.
poly
In the acute hepatitis pattients group, serum from every patient was tested for the presence of
HBsAg and anti HBc (Igm) to establish the diagnosis of HBV infection. Serum samples were then
tested for anti HAV (IgM)to establish the diagnosis of HAV infection. Serum samples negative for
both HBV and HAV were tested for the presence of anti CMV (IgM), Heterophil antibodies of EBV and
anti HCV (IgM).
HBV is the most common cause of acute hepatitis and occured in 62.5% of patients.
Acute hepatitis A occurred in 10% of patients, yet this does not reflect the true status of HAV
infection in Egypt
So we studied the sera for IgG antibodies against HaV,
97.5% of patients found positive for HAV (IgG) indicating previous infection (which is most often
asymptomatic)
HANBH is common in acute hepatitis patients occurring
in 25% of cases. Only 2.5% was due to HCV leaving 22.5% of patients without an identified virus
This indicates that future studies are needed to identify the reset of the offenders in HAHBH
125
Every patient in the post viral hepatitis group was tested for the presence of HBsAg, anti HBc
and anti HCV .
85% of these patients was diagnosed as HBV and 15% was diagnosed as HCV. This reveals a low
incidence of HCV as a cause of sequelae of acute viral hepatitis in co•parison with HBV inspite of
being the main caustive agent of post transfusion hepatitis.
As regards the polytransfused group, 81 B thalassemia
major patients received 9-12 units of packed RBCsjyear. 3.7% were positive for anti HBc antibodies,
8.6\ were positive for anti HBs antibodies and 69.% were positive for anti HCV antibodies.
These resuelts indicate that polytransfused patients
have the highest risk for developing HCV infection
Screening of blood donors for HBV helped the decrease of HBV infection. Screening should also
include testing blood for HCV by detection of anti HCV antibodies, Sometimes the antibodies alone
is not sufficient since it may appear late. Thus it is advised to measure ALT in blood donora to
inform us about the liver status (Alter and Sampliner, 1986)
No patient of the normal healthy children group had anti HCV antibodies .
Thus HCV infection is the main caustive agent of viral hepatitis In patients with repeated blood
transfusion, while it is the caustive agent in only 15% of post viral hepatitis patients and it is
the caustive agent in only .5 % of acute viral hepatitis patients in the present study.