الفهرس 
IntroductionOnly 14 pages are availabe for public view
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Abstract
It is well known that genetic sex which is
establishe:: at the mo:nent of fertilizatior::, deteraines
gonadal sex and ’iat gonadal sex, in turn ,
determines the establish:::lent of phenotypic sex, in
which the mature male o~ female phenotype is developed.
Any disturbance during embryogenesis of one
of the stepes in this development may be reflected
clinically as a disorder of sexual di ffe~entiation.
There are a variety of known mechanisms by which
abno~alities in huoan development can arise: an
environmental insult, as in the ingestion of a virilizing
dr:J.gs during p~egnancy, non fa>1liliel abe:::-rations
of ’he sex chro::~oso:nes, as in 45 :x 0 gonadal dysgenesis,
developmental birth defects of multifactorial
origin, as in most cases of hypospadies, or hereditary
disorders resulting fro:n signle-gene mutations,
as in the testicular feminization s.yndrome.