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Abstract Anemia of chronic renal failure ia one of the mc;t disturbing problems to both the patient and the doctoc because of the complications afecting the patient and the difficulty of treatment by the doctor. This work is designed to study different hematological parameters in 40 chronic renal failure patients on maintenance hemodialysis program and to find out a correlation with different factors, as degree of renal impairement, etiology of renal disease, and duration of dialysis. The patients were under regular hemodialysis in Ain Shams University Hospitals, Military Hospital and other some private dialysis centers. The following was done for all patients included in this work :- al History taking. b) Full clinical examination. c) Full blood picture including RBCs count , HB\, HB in gms, blood indices, HCT\, WBCs count, platelet count and reticulocytic count. 90 d) Blood chemistry tncludinq blood •uea, eerum crea”ini and creatinine clearance. There vas also 15 normal healthy volunteers. A them had no history of renal or hematolo ical disorders systemic disease, no apparent endocrinopathy and wer taking any haematinics or medications known to infl renal and endocrine function. The follovin investiga were done to the control group 1- Full blood picture including RBCs count, HB,, HB in blood indices, HCT\, and reticulocytic count. 2- Blood chemistry including blood urea and creatinine. from the results the following could be observed * Anemia vas a universal finding in all the 40 patients * Anemia in most patients was normocytic normochromic little variation in cell size [MCVI which may increas decrease with co-existing folate or iron deff1c1ency. we advise that more investigations should be done incl measurements of trace elements [specially iron) and vitamins !specially vitamin bl2, and folic acid relation to blood indices. 91 * Anemia of patients 111th polycystic k 1<jneys 1:: <)ft ’n mi than that of others with chronic renal failure. * No significant relatioship was found between HCT % an duration of dialysis. There is a direct highly signifi relation bet11een reticulocytic count and creat clearance. Thus we may predict a hyperproliferatlve sta bone marro11 in patients with chronic renal failure a beginning of dialysis. * There vas no significant relationship between HB\ HCT\ and blood urea, serum creatinine or creat clearance in chronic renal failure patients under re hemodialysis program. Hovever, this is not the sitluatl patients with chronic renal failure not yet needing dia whose HCT\ is im ,,rs lly related to degree of impalreCl function. This indicates that hemodialysis does blunt relation between HCT\ and serum creatinine, blood ure creatinine clearance. * There is a decrease in platelets count with the ris blood urea. * There is a tendency to pancytopenia in most patients chronic renal failure under maintenance hemodia program. 92 * Total WBCs count dec ease with inc ease d· at i dialysis. *’ Total WBCs count decrease with the increase in creatinine. from the last tvo results ve may predict inc llablllty of infection vlth Increase dialysis duration increase serum creatinine ln hemodialysis patients. |