الفهرس 
INTRODUCTIONOnly 14 pages are availabe for public view
 |  | from | 200 |  |  |
| | | from | 200 | | |
Abstract
INTRODUCTION ANn AIM OF THE WORK
The ~_-!umplllg of qJ.phy lococCJ 1r1 the prc-;ence of plw_sma
\\a:-o l)bservcd early by \1uch ( 19’)8). It was later demonstrw_tcd
by Outhte ( 1954-) th<lt th1s phenomenon IS due to the actiOn of two
types of coagulases produced by Staphylococcus aureus: a bound
coagulase {bound to the cell surface), known as the clumpmg factor,
and a free coagulase secreted extraccllularly and known as staphylocoagulase.
He tndicated that both coagulases are dtfferent m the1r
rnechan1srns of actwn and antigen1c propertJes.
Several mvesttgators have tsolated and characterized staphylocoagula<;
e but w1th dtfferent molecular wctght values. Reeves et
ol. (1981) reported four dtsttnct molecular forms of the clotttng
actt\’Jty of <;tram 104 wh1ch differ tn s1ze and shape but not m
charge. They postulated that the term coagulase may actually
represent a famtly of very different protems that have
ablilty to ’>ttmulate clottmg.
sJmdar
Knowledge of the bwcherliJcal and enzymatiC propcrt1es
<Jf staphylocoagulase J’> sttll lnn1ted although many serologtcal arld
hacterJOiogJCal stud1es have been reported (Kawabata et a!.. 1985 c