الفهرس 
IntroductionOnly 14 pages are availabe for public view
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Abstract
Th~ cytoiDgic ~:xaminatlon has been regarded for many years as a
highly accurate method able to detect cervical epithelial atypias. In later
ye.1rs, however, several authors have reported high rates of false negative
c:xarnln::uions (Rubio, 1976). Also false po:.;itive cervical cytology is a
kno\vn infrequently discussed cytodiagnostic problem (Feldman et a[.,
1977).
In cases with borderline lesions (mild and moderate dysplasias) of the
uterine cervix, cytomorphology alone is often not sufficient for the early and
definite cytologic detection of malignancy. For these cases, nonmorphologic
method is needed to distinguish between definitely precancerous or malignant
lesions and nonspecific cellular changes in cytologically-similar smears. The
methods should be applicable to the original cytologic samples, without the
need for repeated smears or further biopsy procedures. Dr\ A cytomctry is
generally accepted as a diagnostic aid in doubtful cases, and an aneuploid
DNA distribution pattern is widely accepted as an indicator of malignancy
(Hocking et al., 1986).
For many years. the determination of the D~’A content of cells and
tissues has heen feasible, but the task has been tedious. Lately, there has been
a resurgence of interest in 0.\TA evaluation in many types of lesions; in an
effort to relate diagnosis and prognosis to DNA ploidy. This renders DNA
ploidy assessment a clinically useful and cost-effective diagnostic and
prognostic test (Wied et al., 1983). Measurement of these DNA content
abnormalities on a cell-by-cell basis, often independent of conventional
histologic criteria or tumor sta.ge, has been advocated as an important
prognostic tool for the assessment of tumor behavior (Wersto, 1988).