الفهرس 
INTRODUCTIONOnly 14 pages are availabe for public view
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Abstract
Mandibular bone defects are a common problem encountered by oral and maxillofacial surgeons. The repair of bony defects in the craniofacial skeleton is a major challenge in maxillofacial surgery, for traditional grafting techniques requires substantial time and effort with associated risk of morbidity. So, the issue of bone regeneration is at the forefront of current tissue engineering applications. Mesenchymal stem cells (MSCs) have the ability to differentiate into various specialized mesenchymal tissue types including the osteogenic cell lineage. Through the application of multipotent competent cells (MSCs) and synthetic or natural biomaterials, surgeons hope to provide a promising alternative to circumvent many of the limitations of current therapeutic modalities aiming at improving the clinical outcomes. Through the assessment of the bone regeneration outcomes achieved by repairing mandibular critical sized defects using bioengineered bone substitutes (MSCs/ β-TCP constructs); we could evaluate the role of autogenous, bone-marrow derived undifferentiated mesenchymal stem cells transplantation in the repair of mandibular bone defects; experimentally in the rabbit model. This study utilized adult New Zealand White rabbits for radiographic and histological evaluation of bone bioengineering for mandibular critical sized defect reconstruction using β-tricalcium phosphate scaffold alone and when loaded with autogenous; bone marrow derived undifferentiated mesenchymal stem cells.