الفهرس 
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Abstract
Although AlCl3 is widely used, research has attached various side effects to them. The aim of this study was to investigate the cytogenetic effects of AlCl3 in mice and the protective role of vit. C against these effect. Fifty-six Swiss albino mice were exposed to AlCl3 alone or in combination with vit. C at doses of 400 mg/kg b.wt. (1/10 LD50), 800 mg/kg b.wt. (1/5 LD50) for 24 and 48 hrs and 200 mg/kg b.wt. (1/20
LD50) for 3 months (chronic treatment), vit. C was used with the different doses of AlCl3 at a dose of 10
mg/day. Bone marrow samples at different times (24, 48 hrs and three months respectively) were obtained.
The results showed that AlCl3 increase the number of structural and numerical chromosomal aberrations.
AlCl3 also decrease the rate of cell division (mitotic index) at (24, 48 hrs and three months respectively).
Moreover, the use of vit. C gave promising results against AlCl3 toxicity as it significantly decreased the frequency of chromosomal aberrations. Random Amplified Polymorphic DNA (RAPD) marker was used
ten random primers to detect genotoxicity caused by chronic exposure to AlCl3 and the effect of vit. C in
mice.
The results showed that The lowest distance was 4.35 and was observed between vit. C treated and
negative control groups. However, the highest genetic similarity was observed between vit. C treated
group and negative control groups, while the lowest was observed between AlCl3 1/20 LD50 + vit. C and
negative control group.