الفهرس 
AcknowledgmentOnly 14 pages are availabe for public view
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Abstract
Type 1 diabetes mellitus (T1DM) is a multifactorial
autoimmune disease characterized by T cell mediated
destruction of the insulin secreting β cells of the islets of
Langerhans in the pancreas. The destructive process leads to
severe insulin depletion and the clinical onset of T1DM occurs
when more than 80% of the β cells have been destroyed.
Protein tyrosine phosphatase non receptor type 22 (PTPN22)
gene encodes lymphoid protein tyrosine phosphatase (LYP) and
is considered to be a critical negative regulator of TCR signal
transduction. A variant of PTPN22 (1858T) has been associated
with the development and progression of T1DM. This variant is
a single nucleotide change at residue 1858 from cytosine to
thymidine, which results in a single amino acid substitution
from arginine to tryptophan at position 620 of the Lyp protein
(R620W) suggesting that the polymorphism confers a gain-of
function form to the protein.
The aim of This study was to analyze the PTPN22 C1858T gene
polymorphism in Egyptian paediatric patients with type 1
diabetes and its association with diabetic complications.