الفهرس 
HematopoiesisOnly 14 pages are availabe for public view
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Abstract
The CBC is commonly ordered during the neonatal period. It not only provides absolute values, but it can also identify changes in the cellular morphology of the erythrocytes, leukocytes, and thrombocytes. Generally, the CBC is an easy test to obtain in the nursery from a capillary, venous, or arterial sample. In view of the many benefits and oddities of the CBC, A variety of factors such as the maternal history, the individual neonate’s perinatal course, mode of delivery, sample site, timing of the sample, gestational age, and the neonate’s degree of health can affect the CBC. Neonatal samples in general laboratories constitute a small proportion of the overall laboratory load, they bring preanalytic, analytic, and postanalytic challenges that are considerable and need to be more widely known and understood for proper testing and result interpretation. Therefore, the practitioner must be able to recognize the clues and nuances of the CBC to guide the diagnostic assessment. Hematologic values in neonates differ significantly from those in older children and adults. Quantitative and qualitative differences are present as a reflection of the developmental changes during foetal haematopoiesis so, correlation with gestational age is essential. This study was done to evaluate the effect of mode of delivery as one of preanalytical causes that may influence the neonatal CBC. Also we gave a spot on the differences of CBC parameters between full term and preterm, differences of CBC regarding sex, correlation between CBC and birth weight and correlation between CBC and gestational age. The present study was carried out at Paediatric and Clinical Pathology departments, Faculty of medicine, Menoufiya University. This study included neonates delivered in obstetrics and gynaecology department in Menoufiya University hospital. They were divided into two groups according to the mode of delivery either full term or preterm. Full history, clinical examination, CBC was done to all neonates. The results of this study can be summarized as follows: As regard fullterm neonates: significant difference between full term neonates delivered normal vaginal and caesarean section regarding HGB, RBC, HCT, PLT, TLC, Neutrophils , Eosinophils and Basophils .while, no significant difference regarding MCV , MCH, MCHC, RDW, Lymphocytes and Monocytes. As regard preterm neonates: significant difference between preterm neonates delivered normal vaginal and caesarean section regarding HGB, RBC, HCT, MCV , MCH, RDW, PLT, TLC, Neutrophils , Eosinophils and Lymphocytes.while no significant difference regarding MCHC, Basophils and Monocytes . All the significant values were higher in those delivered by normal vaginal delivery than those by caesarean section. As regard neonates delivered by normal vaginal delivery: Hb, RBC, MCH, PLT and TLC were significantly higher in full term neonates delivered by normal vaginal delivery than preterm neonates. While MCV was higher in preterm neonates than full term. There was no statistical significant difference regarding HCT, MCHC, RDW, Lymphocytes, Neutrophils, Eosinophils, Basophils and Monocytes. As regard neonates delivered by caesarean section: Hb, RBC and TLC were significantly higher in full term neonates delivered by caesarean section than preterm neonates.While MCV was higher in preterm neonates than full term. While no statistical significant difference regarding HCT, MCHC, MCH, PLT, RDW, Lymphocytes, Neutrophils, Eosinophils, Basophils and Monocytes. In this study there was significant statistical correlation between CBC parameters and gestational age of neonates. There was positive correlation between newborn gestational age and Hb,RBC,HCT and TLC. Also negative correlation between gestational age and MCV. In this study there was positive significant statistical correlation between CBC parameters and weight of neonates regarding Hb, RBC and TLC. In this study there was no significant statistical correlation between CBC parameters and the gender of neonates.