الفهرس 
Liver cirrhosisOnly 14 pages are availabe for public view
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Abstract
Background: An acid base and electrolyte disturbances occur frequently in the setting of
liver diseases. As liver’s metabolic function worsen, particularly in the setting of renal dysfunction,
haemodynamic compromise, and hepatic encephalopathy, acid base disorders ensue.
Methods: The present study was conducted on 60 cirrhotic patients were selected from the
200 patients, as well as 20 healthy persons as a control group. Diagnosis of cirrhosis was done by
clinical examination, ultrasonographic findings and laboratory investigations. Patients and controls
were classified into the following groups: Group I: comprised 60 cirrhotic patients, they were
subdivided into 3 subgroups according to Child-Pugh classification: Group Ia: 20 cirrhotic
patients (child’s A), Group Ib: 20 cirrhotic patients (child’s B), Group Ic: comprised 20 cirrhotic
patients (child’s C), Group II: comprised 20 healthy controls. Patients and controls were subjected
to the following: Full history taking, Thorough clinical examination (general and local abdominal
examination), Abdominal ultrasound ,Laboratory investigations including: CBC , Liver function
tests namely ALT, AST, s.bilirubin , s.albumin , INR level , serum creatinine, Serum electrolytes
:Na+, K+ . ABG to evaluate blood PH, HCO3,PCO2 and PO2.
Results
• Manifestations of liver cell failure were present in various proportions of cirrhotic groups.
• There was highly significant difference in PH, PCO2, PO2, HCO3and SO2 between both
groups.
The common acid base disorder is respiratory alkalosis. However, other disorders can be
seen.
Change in acid base balance as following:
Child’s A group: no change in acid base balance.
Child’s B group: 75% no changes in acid base balance. 20% respiratory alkalosis. 5%
metabolic alkalosis.
Child’s C group: 70% respiratory alkalosis.15% respiratory acidosis. 15% metabolic
alkalosis.
Conclusion
These result declare the presence of multiple and mixed acid base disorder.