الفهرس 
Structure of ER? and ER?Only 14 pages are availabe for public view
 |  | from | 191 |  |  |
| | | from | 191 | | |
Abstract
Breast cancer is one of the most commonly diagnosed cancers comprising 23% of all the female cancers and the second leading cause of cancer deaths in women worldwide today. Several studies have established that estrogens are predominantly involved in the initiation and proliferation of breast cancer and much effort are now being advoted to block estrogen formation and actions.
On the other hand, pyrazole-containing compounds have received considerable attention owing to their diverse chemotherapeutic potentials including versatile antineoplastic activities. In addition, it has been reported that certain pyrazoles exhibit ERα selective agonism. Structure modification of this ERα selective scaffold was considered relevant to prepare ERα selective antiestrogens. In view of the aforementioned facts, it is reported herein, design, synthesis and evaluation of novel triarylpyrazole derivatives for their uterotrophic and antiuterotrophic activities, besides selected compounds were screened for their anticancer activities.
The present thesis is subdivided into the following chapters:
Chapter 1:
Introduction:
Introduction presented a brief literature review describing the biologically and pharmaceutically active nonsteroidal antiestrogens.
Chapter 2:
Research Objectives:
This chapter indicated the rationale upon which the newly synthesized compounds were designed and prepared. The compounds were designed based on triarylpyrazole chemical scaffold that demonstrated very high ERα selectivity.
Chapter 3:
Discussion:
In this chapter, the theories upon which the design and synthesis of the intermediates and final compounds were presented. References were made to the knowledge available in literature as well as the confirmation of the structures of newly synthesized compounds by different chemical and spectral means. Besides, references were made to previous efforts made in our laboratory in this field.