الفهرس 
Mechanism of action and pharmacology
Formulation of solid dispersionsOnly 14 pages are availabe for public view
 |  | from | 144 |  |  |
| | | from | 144 | | |
Abstract
The purpose of this study was to increase solubility of Glibenclamideby solid dispersion technique and formulating it as a floating tablet. The acidic nature of the drug resulted in a narrow absorption window with the drug having higher chance of absorption -#102;-#114;-#111;-#109; the upper part of the gastrointestinal tract. Accordingly, preparation of floating system is expected to be highly beneficial. Unfortunately, the poor solubility of the drug can limit its dissolution in the stomach which will hinder the ability to control the release after floatation. Accordingly, the study strategy was to enhance the dissolution rate of the drug, then incorporating the optimum formulation in a floating tablet. This employed the solid dispersion technique using Poloxamer 407 as the hydrophilic polymer. Three binary systems of drug and poloxamer were prepared at 1:1, 1:2 and 1:4 w/w ratios, respectively Ternary dispersion was prepared by the addition of sodium bicarbonate as third component. Physical mixture of bicarbonate and drug was also prepared for comparative purposes. Solid state -#99;-#104;-#97;-#114;acterizations were performed using Differential Scanning Calorimetry (DSC) and Infra-Red spectroscopy (IR). For DSC, all solid dispersions reduced the Tm of the drug and lowered the enthalpy of the endothermic peaks indicating possible transformation of the drug -#102;-#114;-#111;-#109; crystalline to amorphous form or eutectic mixture formation. Infrared study suggested no interaction between the drug and polymer.