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Abstract Enzymes are special proteins that catalyze the digestibility of a wide range of feed components such as fiber, phytate, protein in nonruminants diets. Fiber-degrading enzymes were used to break down specially non-starch polysaccharides (NSP), which are large polymers, to smaller polymers to alleviate their anti-nutritive activities. A total of 160, one day old commercial Cobb broiler chicks were divided into 8 equal groups in a 6 weeks feeding trial to investigate the effect of addition of the feed Enzymes (HerizymR), with or without antibacterial or anticoccidial drugs, on enhancing the feed efficiency and controlling the hazardous effect of Salmonella infection or Eimeria infestation of broiler chicks. The obtained results indicated that dietary enzymes addition to broiler ration exposed to Salmonella infection or Eimeria infestation improved growth performance, decreased bacterial count and Eimeria oocyte shedding, and enhanced Lactobacillus count. Antibiotic and anticoccidial with enzyme addition had good recovery effect on histopathological finding in liver and intestine of broilers. It could be concluded that enzyme dietary addition, with or without antibacterial and anticoccidial drugs, ameliorated the hazardous effect of Salmonella infection or Eimeria infestation on performance and on histopathological finding in liver and intestine of broilers. |