الفهرس 
?-AminophosphonatesOnly 14 pages are availabe for public view
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Abstract
The present thesis comprises three main chapters in addition to English and Arabic summaries as well as appendix and relevant references. The First Chapter: - Introduction This chapter includes an updated literature survey related to α- aminophosphonates and their metal complexes regarding their synthesis, stability of their metal complexes, their chemical and biochemical importance. The Second Chapter: - Results and Discussion This chapter covers the results obtained and their discussion - The α-aminophosphonate ligands obtained from reactions of aryl aldehydes with amines and triphenylphosphite in the presence of lithium perchlorate, as a Lewis acid catalyst .Their Cu(II) complexes have been prepared by the reaction of aminophosphonate ligands with different Cu(II) salts .The structure of these compounds was investigated by different analytical and spectral methods. The thermal behavior of the investigated complexes has also been studied,and the obtained results showed that:- 1. The ligands and their complexes are air stable, non-hygroscopic and insoluble in most common organic solvents . 2. The analytical and spectral data (MS, 1H NMR and IR) confirm the formation of α-aminophosphonate ligands and their corresponding copper(II) complexes. 3. The results of elemental analyses showed that the complexes present in 1:1 or 1:2 or 2:1 (M:L) molar ratio. 4. The relatively low molar conductance values showed that all complexes have non-electrolytic nature except for complexes 21, 25 which are 1:1 electrolytes and complexes 15, 19, 24 which are 1:2 electrolytes. 5. On the basis of spectral studies, a distorted square planar geometry has been assigned for all the complexes. 6. The thermal behavior of the ligands and its complexes showed good agreement with the formula suggested from the analytical, spectral and magnetic data. The decomposition temperatures of the complexes lie in the range (130-330 °C) - The metal-free ligands and their Cu(II) complexes were further tested for their in vitro anticancer activity against human colon carcinoma HT-29 cell lines. The results showed that most of the synthesized copper(II) complexes exhibited significantly higher anticancer activity than their free ligands. - Among all the tested compounds in the series, the complex 16 demonstrated the highest anticancer activity at low micromolar inhibitory concentrations (IC50 = 14.2 μM) which is about a half of the reference drug activity, cisplatin (IC50 = 7.0 μM) in the same assay. NH Cu O O P PhO OPh O OH2 The Third Chapter: - Experimental This part includes: - A detailed account about the method of preparing α-aminophosphonate ligands and their metal complexes with different copper(II) salts. -Characterization of the structure of the ligands and their metal complexes as elemental analysis, spectral (IR, UV-Vis, MS, EPR and 1H NMR) techniques, magnetic moment, molar conductivity measurements and thermal techniques (TG/DTG).