الفهرس 
Chapter 1: General Introduction
Historical backgroundOnly 14 pages are availabe for public view
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Abstract
In the presented thesis, four methods were developed for the analysis of
some non – sedating antihistamines (NSAs) namely; cetirizine (CTZ),
ebastine (EBS), fexofenadine (FXD), ketotifen (KET) and loratadine
(LOR).
ü A simple, sensitive and non-extractive spectrophotometric method
has been developed for the determination of CTZ, EBS, FXD, KET
and LOR based on ion-pair complex formation with erythrosine B.
ü A validated simple, rapid, and selective spectrofluorimetric method
was developed for the determination of CTZ, EBS, FXD, KET and
LOR. The method is based on quenching effect of the cited drugs
on the fluorescence intensity of erythrosine B (EB) and
measurement of ΔF.
ü A validated simple, rapid, and selective spectrofluorimetric method
for the determination of some NSAs namely; CTZ, EBS, FXD, and
LOR. The method is based on measuring the native fluorescence of
the cited drugs after protonation in acid media and studying their
quantitative fluorescence intensity – structure relationships. Several
quantitative relationship were found between the relative
fluorescence intensities of the protonated drugs and their
physicochemical parameters namely; the pKa, log P, connectivity
indexes (χv) and their squares. Seventy six regression equations
were obtained and not previously reported. Six of these equations
were highly significant and used for the prediction of RFI of the
studied drugs .