الفهرس | Only 14 pages are availabe for public view |
Abstract Gastric ulcer is the common condition encountered in clinical practice. Ulcers are produced because of the inequity between aggressive and protective factors of the mucosal layer. For many years, aspirin had been recognized for its therapeutic properties. Medications containing Salicylic Acid had been used for a long time in treatment of rheumatic diseases, wounds, menstrual pain and fever. Aspirin can cause damage to the gastro-duodenal mucosa via several mechanisms, including the topical irritant effect of this drug on the epithelium, impairment of the barrier properties of the mucosa, reduction of gastric mucosal blood flow and interference with the repair of superficial injury. In recent years, stem cells in various tissues have been a major focus of discussion in the scientific community. Stem cells have been defined as cells with unlimited capacity for self-renewal without senescence and the ability to differentiate into one or more cell types in vitro and in vivo. The possibility of using stem cells can be improved, allowing better use of this important tool: as in the repair of epithelial tissue after extensive lesions and even in research of mechanism of diseases, drug toxicology screening, among other purposes. Therefore, the present study tried to use a new therapeutic modality to treat resistant gastric ulcer. So, the current study was designed to evaluate the effect of bone marrow mesenchymal stem cells (BM-MSCs) on gastric mucosal damage induced by acetyl salicylic acid. The experiment was conducted on 36 adult albino rats with an average weight of 150 - 200 gm. They were divided into four groups: Group I: (Control group) It included 12 rats, divided into two equal subgroups 6 rats each: Subgroup IA: Animals were given 1ml of 0.9% physiological saline by intravenous injection (tail vein) in an amount used as a solvent for of BM-MSCs. Subgroup IB: Animals were given 1ml of 0.9% physiological saline orally by intra-gastric tube in an amount used as a solvent for of BM-MSCs. In each rat of this group, bone marrow was collected from both tibia and femur and BM-MSCs were cultured. |