الفهرس 
Introduction & Aim of the workOnly 14 pages are availabe for public view
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Abstract
This prospective clinical trial conducted in EL-Minia Infertility and Research centre in El-Minia Maternity and Child Hospital between May 2013 – February 2014.
Fifty infertile women were selected from the women who were attending the infertility centre .All patients were diagnosed as having un- ovulation due to polycystic ovaries (PCOS).
A total 50 women with polycystic ovary syndrome were enrolled into the study, of these 25 patients received clomiphene and 25 patients received letrazole.
Finally, the efficacy of an agent for inducing ovulation should be evaluated by the pregnancy rate. All studies reported similar pregnancy rates in two groups and these data were supported by the meta-analysis. It is thought that this is probably due to the lower number of mature follicles per cycle found in the letrozole group.
There was no significant difference in the abortion rate in the two groups in the meta-analysis. Whether letrozole has harmful or teratogenic effects on the fetus was not reported in any of the included studies. An animal study found that letrozole has toxic effects on prenatal development in rats (Tiboni et al., 2008).
But so far, no embryonic or fetal malformations have been reported in humans. A study published in 2006 examined 514 babies born to mothers who had used letrozole to conceive and compared them with 397 babies born to mothers who had conceived using clomiphene citrate (Tulandi et al., 2006).
There were no increased rates of major and minor malformations in the letrozole group compared with the clomiphene citrate group. Additionally, the number of cardiac anomalies in the letrozole group was slightly lower than in the clomiphene citrate group. As a result, letrozole can be seen as a safe agent for ovulation induction like clomiphene citrate.
This study provides, as far as is known for the first time, quantitative estimates of the efficiency of letrozole in ovulation induction for PCOS.