الفهرس 
IntroductionOnly 14 pages are availabe for public view
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Abstract
Biochemical influence of resveratrol, rutin and curcumin on lipid peroxidation and antioxidant enzymes in blood and colon tissue of trinitrobenzene sulfonic acid-induced colon mucosal erosions in rats were investigated. Moreover, the possible protective and therapeutic effects of resveratrol, rutin and curcumin on serum nitric oxide, colon tissue LMalondialdehyde, enzymatic and non-enzymatic antioxidant , NF-kB P , serum tumor necrosis factor-alpha, interleukin- β, colon tissue myeloperoxidase activity, sialic acid, in addition to DNA fragmentation, caspase- , -hydroxy- deoxyguanosine, cyclo oxygenase- and Lactate dehydrogenase in colon tissue in a rat model of TNBS-induced ulcerative colitis were also evaluated. Eighty white male rats, - weeks old and average body weight- g were used in the experimental investigation of this study. Rats were housed in separated metal cages and kept at constant environmental and nutritional conditions throughout the period of experiment. The animals were fed on constant ration and water was supplied ad- libitum. The animals were left days for acclimatization before the beginning of the experiment. Trinitrobenzene sulfonic acid-induced ulcerative colitis: After hours of fasting, the rats were anesthetized by intraperetinoel injection of sodium thiopental ( mg dissolved inml of normal saline) at the dose level of ml/ gm body weight ( mg/kg b.wt i.p.). To induce colitis, the rats were intracolonically treated with ml of ( mg/kg b.wt) of TNBS via a cannula that was placed cm proximal to the anus using a rectally inserted flexible polyethylene catheter. Rats were positioned head-down for - minutes to preclude immediate anal leakage of the instillate and thereafter returned to their cages with access to food and water ad libitum. Also, ml physiological saline was intracolonically administered to the rats in the control group via a cannula.