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العنوان
Study of CD123 Expression in B-Cell in Acute Lymphoblastic Leukemia /
المؤلف
Hussien, Amal Moustafa Tohamy.
هيئة الاعداد
باحث / أمل مصطفي تهامي حسين
مشرف / محمد كمال زهرة
مشرف / محمد رمضان الشنشورى
مشرف / أميرة يوسف أحمد
الموضوع
Clinical Pathology. Clinical pathology.
تاريخ النشر
2014.
عدد الصفحات
p 164. :
اللغة
الإنجليزية
الدرجة
ماجستير
التخصص
الطب (متفرقات)
تاريخ الإجازة
14/1/2015
مكان الإجازة
جامعة طنطا - كلية الطب - Clinical pathology
الفهرس
Only 14 pages are availabe for public view

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from 205

Abstract

Acute lymphoblastic leukemia (ALL) is a hemopoetic disorder characterized by a block in differentiation of hemopoiesis, resulting in growth of clonal population of neoplastic cell or
blasts.
Moreover, (WHO) classification for ALL added the genetic,
immunophenotyping, biological and clinical feature to the
morphological finding.
Immunophenotyping has became an important diagnostic tool
in establishing the diagnosis and classification of acute
lympoblastic leukemia.
CD 123 is an 0. subunit of a heterodimcr IL-3 receptor, a
member of the cytokine receptor superfamily. IL-3 is known to
be involved in proliferation and maturation of human 8 cells.
B-lymphoid blasts from acute lymphoblastic leukemia (ALL)
have been shown to express functional CD 123
The purposes of the present study were to examine the
expression of CD 123 on newly diagnosed 8 -cell ALL cases by
flow cytometry.