الفهرس 
INTRODUCTIONOnly 14 pages are availabe for public view
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Abstract
Beta(β)-thalassemia is the most widespread autosomal recessive hereditary disease, and it is characterized by reduced (β+) or no (β0) β globin chain synthesis. These conditions cause varying degrees of anemia. Patients with severe anemia who receive regular blood transfusions become iron overloaded, the presence of non-transferrin-bound-iron (free iron) in serum generates free radicals which, in turn, cause oxidative vessel injury and lowers antioxidant levels in their bodies. Free oxygen radicals act directly on the endothelial cells and have a close interaction with lipid peroxidation, causing a modification of low-density lipoprotein (LDL-C) and facilitating LDL-C deposition, with the consequent formation of atherosclerotic plaques.