الفهرس 
Material and MethodsOnly 14 pages are availabe for public view
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Abstract
The aim of this study was to evaluate the effect of sleep deprivation on
vascular reactivity in adult male albino rats. This study was conducted on
140 adult male albino rats (200g +10). Rats were divided into four
groups:
Group (I): Control group.
Group (2): Sleep deprived group.
Group (3): Sleep recovery for 24 hours.
Group (4): Sleep recovery for 48 hours.
In each of the previously mentioned groups, systolic, diastolic and
mean arterial blood pressures, vascular reactivity to noradrenaline,
indomethacin, vasopressin, ACh and sodium nitropresside, serum
adrenaline, noradrenaline, ACTH, cortisone and C ‐ reactive protein were
studied.
The results showed that induction of sleep deprivation was associated
by significant increase in systolic, diastolic and mean arterial blood
pressures, significant increase in the vascular reactivity to noradrenaline,
vasopressin and indomethacin. The percentage of vasodilation to ACh
significantly decreased. Serum levels of adrenaline, noradrenaline, ACTH,
cortisone and C ‐ reactive protein significantly increased.
In twenty four hour recovery group, systolic, diastolic and mean arterial
blood pressures still significantly elevated. Also, vascular reactivity to
noradrenaline, vasopressin and indomethacin were still significantly high. C-reactive protein also still significantly elevated, while adrenaline
and noradrenaline returned to control levels.
With eighty four hour recovery, blood pressure, vascular reactivity, C ‐
reactive protein, adrenaline and noradrenaline returned to control
levels.